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Role of the funding source This work was partially supported by National Health and Medical Research Council (NHMRC) Grants GNT1105321 and GNT1012245 (P.A.W.R., G.W.M., J.E.G., S.J.H-C.), GNT1026033 (G.W.M.) and NHMRC Medical Research Future Fund GNT1199715 (P.A.W.R., M.H., S.J.H-C

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